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Invitrogen

LKB1 Recombinant Rabbit Monoclonal Antibody (PSH09-29)

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LKB1 Recombinant Rabbit Monoclonal Antibody (PSH09-29)

Product Details

MA562889

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:1,000
-

Immunoprecipitation (IP)

1-2 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

PSH09-29

Immunogen

Recombinant protein within human LKB1 aa 1-400.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 0.1% BSA, 40% glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3715103

Product Specific Information

Positive Control: K-562 cell lysate, Jurkat cell lysate, HEK-293 cell lysate, COS-1 cell lysate, Mouse brain tissue lysate, Mouse testis tissue lysate, Rat testis tissue lysate, human testis tissue, mouse testis tissue, rat testis tissue.

Tissue Specificity: Low tissue specificity

Subcellular Location: Nucleus, Cytoplasm, Membrane, Mitochondrion.

Sequence Similarities: 92% Mouse/Rat

Predicted band size: 49 kDa.

Target Information

LKB1 (also known as STK11 - Serine/threonine-protein kinase STK11), a member of the serine/threonine kinase family, is a tumor suppressor. LKB1 physically associates with p53 and regulates specific p53 dependent apoptosis pathways. LKB1 is present in both the cytoplasm and nucleus of living cells and translocates to mitochondria during apoptosis. LKB1 functions as a master upstream protein kinase, regulating AMPK related kinases as well as AMPK. Mutations in LKB1 gene are associated with Peutz Jeghers syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CAMK group; CAMKL family; Liver kinase B1; Liver kinase B1 homolog; LKB 1; LKB-1; LKB1; LKB1(S); polarization-related protein LKB1; Renal carcinoma antigen NY-REN-19; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1; Serine/threonine-protein kinase STK11

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Gene Aliases: AA408040; hLKB1; LKB1; Par-4; PJS; R75140; STK11

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UniProt ID: (Human) Q15831, (Rat) D4AE59, (Mouse) Q9WTK7

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Entrez Gene ID: (Human) 6794, (Rat) 314621, (Mouse) 20869

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Function(s)
magnesium ion binding p53 binding protein serine/threonine kinase activity protein binding ATP binding LRR domain binding protein kinase activator activity protein complex binding
Process(es)
regulation of cell growth tissue homeostasis vasculature development protein phosphorylation autophagy cellular response to DNA damage stimulus cell cycle arrest spermatid development axonogenesis negative regulation of cell proliferation response to ionizing radiation establishment of cell polarity regulation of Wnt signaling pathway negative regulation of cell growth positive regulation of transforming growth factor beta receptor signaling pathway activation of protein kinase activity response to glucagon response to lipid TCR signalosome assembly glucose homeostasis anoikis response to peptide hormone positive thymic T cell selection positive regulation of gluconeogenesis positive regulation of protein kinase activity protein autophosphorylation regulation of dendrite morphogenesis positive regulation of peptidyl-tyrosine phosphorylation positive regulation of axonogenesis T cell receptor signaling pathway protein heterooligomerization Golgi localization regulation of protein kinase B signaling canonical Wnt signaling pathway negative regulation of epithelial cell proliferation involved in prostate gland development cellular response to UV-B intrinsic apoptotic signaling pathway by p53 class mediator dendrite extension positive regulation of protein localization to nucleus positive regulation of autophagy negative regulation of lipid biosynthetic process positive regulation of protein serine/threonine kinase activity regulation of signal transduction by p53 class mediator negative regulation of TORC1 signaling
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