|Flow Cytometry (Flow)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||1-10 µg/mL|
|Immunohistochemistry (Paraffin) (IHC (P))||1-10 µg/mL|
|Western Blot (WB)||1-5 µg/ml|
|Flow Cytometry (Flow)||See 1 publications below|
|Neutralization (Neu)||See 1 publications below|
|Tested Species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Human LRP/alpha2 MR.|
|Storage buffer||PBS, pH 7.4|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
MA1-27198 detects Low Density LRP from human samples.
MA1-27198 has been successfully used in immunohistochemistry (paraffin and frozen), flow cytometry, blocking assay, immunocytochemistry, immunofluorescence and Western blot procedures. Perform Western blot analysis under non-reducing conditions.
The MA1-27198 immunogen is human LRP/alpha2 MR.
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: A2MR; Alpha-2-macroglobulin receptor; APOER; Apolipoprotein E receptor; APR; CD91; FLJ16451; IGFBP3R; low density lipoprotein receptor-related protein 1; LRP-1; MGC88725; Prolow-density lipoprotein receptor-related protein 1; TbetaR-V/LRP-1/IGFBP-3 receptor; TGFBR5; type V tgf-beta receptor
Gene Aliases: A2MR; APOER; APR; CD91; IGFBP3R; LRP; LRP1; LRP1A; TGFBR5
UniProt ID: (Human) Q07954
Entrez Gene ID: (Human) 4035
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