|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Human LRP/alpha2 MR.|
|Storage buffer||PBS, pH 7.4|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||1-10 µg/mL|
|Immunohistochemistry (Paraffin) (IHC (P))||1-10 µg/mL|
|Western Blot (WB)||1-5 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-27198 detects Low Density LRP from human samples.
MA1-27198 has been successfully used in immunohistochemistry (paraffin and frozen), flow cytometry, blocking assay, immunocytochemistry, immunofluorescence and Western blot procedures. Perform Western blot analysis under non-reducing conditions.
The MA1-27198 immunogen is human LRP/alpha2 MR.
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.