|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Human LRP/alpha2 MR.|
|Storage buffer||PBS, pH 7.4|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||1-10 µg/mL|
|Immunohistochemistry (Paraffin) (IHC (P))||1-10 µg/mL|
|Western Blot (WB)||1-5 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-27198 detects Low Density LRP from human samples.
MA1-27198 has been successfully used in immunohistochemistry (paraffin and frozen), flow cytometry, blocking assay, immunocytochemistry, immunofluorescence and Western blot procedures. Perform Western blot analysis under non-reducing conditions.
The MA1-27198 immunogen is human LRP/alpha2 MR.
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Human CD1c(+) DCs are critical cellular mediators of immune responses induced by immunogenic cell death.
MA1-27198 was used in flow cytometry investigate the impact of CD1c positive dendritic cells on immunogenic cell death
|Di Blasio S,Wortel IM,van Bladel DA,de Vries LE,Duiveman-de Boer T,Worah K,de Haas N,Buschow SI,de Vries IJ,Figdor CG,Hato SV||Oncoimmunology (5:null)||2016|
Plasma Low-density Lipoprotein Receptor-related Protein 1 Concentration is not Associated with Human Abdominal Aortic Aneurysm Presence.
MA1-27198 was used in blocking or activating experiment to study the role of low-density lipoprotein receptor-related protein 1 in abdominal aortic aneurysm
|Moxon JV,Behl-Gilhotra R,Morton SK,Krishna SM,Seto SW,Biros E,Nataatmadja M,West M,Walker PJ,Norman PE,Golledge J||European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery (50:466)||2015|