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Immunohistochemistry analysis of LRP1 in 4% PFA, OCT embedded frozen mouse E16.5 lung sections. Sections were blocked and probed with a LRP1 mouse monoclonal antibody (Product # 37-3800) at a dilution of 1:100. Detection was performed using an Alexa Fluor-568-conjugated anti-mouse secondary antibody (A11004).
|Tested species reactivity||Human, Mouse|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Purified human CD91 alpha chain protein.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
|Immunofluorescence (IF)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
37-3800 has been successfully used in immunohistochemistry analysis of LRP1 in mouse E16.5 frozen lung sections.
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
||Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues.||Moestrup SK,Gliemann J,Pallesen G||Cell and tissue research (269:375)||1992|
|Human||Not Cited||Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues.||Moestrup SK,Gliemann J,Pallesen G||Cell and tissue research (269:375)||1992|
A2MR; alpha 2-macroglobulin receptor; alpha-2-macroglobulin receptor; APOER; apolipoprotein E receptor; APR; CD91; FLJ16451; IGFBP3R; lipoprotein receptor-related protein; low density lipoprotein receptor-related protein 1; LRP-1; lrp1; MGC88725; prolow-density lipoprotein receptor-related protein 1; TbetaR-V/LRP-1/IGFBP-3 receptor; TGFBR5; type V tgf-beta receptor
A2MR; AI316852; APOER; APR; b2b1554Clo; CD91; IGFBP3R; LRP; LRP1; LRP1A; TGFBR5