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Invitrogen
LRP1 Recombinant Rabbit Monoclonal Antibody (ARC0275)
Advanced Verification
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 6
LRP1 Antibody (MA5-35053) in ICC/IF
Immunofluorescence of LRP1 was performed using HAP1 WT and HAP1 LRP1 KO cells that were labeled with a green or a far-red fluorescent dye, respectively. WT and KO cells were mixed and plated to a 1:1 ratio on glass coverslips as a mosaic and incubated for 24 hrs. Cells were fixed in 4% PFA (in PBS) for 15 min at RT; cells were permeabilized with 0.1% Triton X-100 for 10 min at RT and blocked with PBS containing 5% BSA, 5% goat serum, and 0.01% Triton X-100 for 30 min. Cells were stained with LRP1 Recombinant Rabbit Monoclonal Antibody (ARC... View More
Product Details
MA5-35053
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
ARC0275
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 4400-4500 of human LRP1 (Q07954)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2848958
Product Specific Information
Immunogen sequence: PPHMTGPRCE EHVFSQQQPG HIASILIPLL LLLLLVLVAG VVFWYKRRVQ GAKGFQHQRM TNGAMNVEIG NPTYKMYEGG EPDDVGGLLD ADFALDPDKP T
Target Information
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A2MR; alpha 2-macroglobulin receptor; Alpha-2-macroglobulin receptor; APOER; Apolipoprotein E receptor; CD91; FLJ16451; lipoprotein receptor-related protein; low density lipoprotein receptor-related protein 1; low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor); LRP-1; lrp1; MGC88725; Prolow-density lipoprotein receptor-related protein 1; TbetaR-V/LRP-1/IGFBP-3 receptor; type V tgf-beta receptor
Gene Aliases: A2MR; AI316852; APOER; APR; b2b1554Clo; CD91; IGFBP3R; LRP; LRP1; LRP1A; TGFBR5
UniProt ID: (Human) Q07954, (Mouse) Q91ZX7, (Rat) G3V928
Entrez Gene ID: (Human) 4035, (Mouse) 16971, (Rat) 299858
protease binding
receptor activity
low-density lipoprotein receptor activity
calcium ion binding
protein binding
protein complex binding
apolipoprotein binding
lipoprotein transporter activity
poly(A) RNA binding
lipoprotein particle receptor binding
metal ion binding
apolipoprotein
extracellular matrix structural protein
transmembrane signal receptor
retinoid metabolic process
receptor-mediated endocytosis
protein kinase C-activating G-protein coupled receptor signaling pathway
aging
cell proliferation
positive regulation of cholesterol efflux
negative regulation of neuron projection development
negative regulation of smooth muscle cell migration
cerebral cortex development
negative regulation of Wnt signaling pathway
positive regulation of lipid transport
regulation of cholesterol transport
regulation of phospholipase A2 activity
regulation of actin cytoskeleton organization
aorta morphogenesis
lipoprotein metabolic process
lipoprotein transport
apoptotic cell clearance
negative regulation of neuron apoptotic process
positive regulation of protein transport
beta-amyloid clearance
negative regulation of platelet-derived growth factor receptor-beta signaling pathway
endocytosis
multicellular organism development
cholesterol metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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