This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
This antibody is predicted to react with Monkey, Cat, Pig.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
LRP130, also known as LRPPRC (leucine-rich PPR motif-containing protein, mitochondrial) plays a role in RNA metabolism in both nuclei and mitochondria. In the nucleus, LRPPRC binds to HNRPA1-associated poly(A) mRNAs and is part of nmRMP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. It may bind mature mRNA in the nucleus outer membrane. In mitochondria, LRPPRC binds to poly(A) mRNA. It also plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. It cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Mutations to the gene result in Leigh syndrome French-Canadian type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 130 kDa leucine-rich protein; leucine-rich pentatricopeptide repeat containing; leucine-rich PPR-motif containing; LRP 130; LRPPRC; mitochondrial leucine-rich PPR motif-containing protein
Gene Aliases: CLONE-23970; GP130; LRP130; LSFC
Entrez Gene ID: (Human) 10128