In direct ELISAs, this antibody shows approximately 50-60% cross-reactivity with recombinant human (rh) LRP-6 and no cross-reactivity with rhLDL R.
Reconstitute at 0.5 mg/mL in sterile PBS.
This gene encodes a member of the low density lipoprotein receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- processing but the precise locations of the cleavage sites have not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ADCAD2; crooked; FLJ90062; FLJ90421; low density lipoprotein receptor-related protein 6; low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6; low density lipoprotein-related protein 6; Low-density lipoprotein receptor-related protein 6; lpr6; LRP-6; LRP6
C030016K15Rik; Cd; Gw; Lrp6; ska26; ska
UniProt ID: (Mouse) O88572
Entrez Gene ID: (Mouse) 16974