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| Applications | Tested Dilution | Publications |
|---|---|---|
Immunocytochemistry (ICC/IF) |
10 µg/mL | - |
ELISA (ELISA) |
0.03 ng/mL | - |
Immunoprecipitation (IP) |
1-5 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Mouse / IgG1, kappa |
Class |
Monoclonal |
Type |
Antibody |
Clone |
3G8 |
Immunogen |
LRRK1 (AAH05408, 560 a.a. approximately 659 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
See Label |
Purification |
Affinity chromatography |
Storage buffer |
PBS, pH 7.4 |
Contains |
no preservative |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
Sequence of this protein is as follows: PGAASDRSEH DLTPMDGETF SQHLQAVKIL AVRDLIWVPR RGGDVIVIGL EKDSEAQRGR VIAVLKAREL TPHGIMPVSS VKVCWAGWPV RDMVYMAAVM
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: leucine-rich repeat kinase 1; Leucine-rich repeat serine/threonine-protein kinase 1; LRRK1
Gene Aliases: KIAA1790; LRRK1; RIPK6; Roco1
UniProt ID: (Human) Q38SD2
Entrez Gene ID: (Human) 79705
Molecular Function:
non-receptor serine/threonine protein kinase
scaffold/adaptor protein
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