|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 14 amino acid peptide from near the amino terminus human LXR-B.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Western Blot (WB)||1-2 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control is human lung tissue lysate.
PA5-20886 can be used with blocking peptide PEP-1000.
LXR-B belongs to the Liver X Receptor family that encodes highly homologous transcription factors. Like the highly homologous LXR-A, LXR-B forms heterodimers with the retinoic acid receptor RXRalpha, which function as sensors for cellular oxysterols which when activated, increase the expression of genes that control sterol and fatty acid metabolism and homeostasis. Recent experiments have indicated that the LXRs can also modulate both innate and adaptive immune responses. Other studies suggest that genetic variability at the LXR-B gene locus may be a risk factor for Alzheimer and quote;s disease. One hypothesis postulates that LXR may be upstream of ApoE and potentiates the risk associated effects of the epsilon3 allele.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.