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|Tested species reactivity||Not Applicable|
|Host / Isotype||E.coli|
|Storage buffer||0.05M tris HCl, pH 7.5, with 10mM L-glutathione|
|Storage Conditions||-20°C or -80°C if preferred|
|Tested Applications||Dilution *|
|Control (Ctrl)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This product is a GST-tagged recombinant protein corresponding to human LYVE-1, aa 243-323.
On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 36kDa.
The pace of research into the lymphatic system continues to accelerate with the availability of new molecular markers. One such marker, LYVE-1, the lymphatic receptor for the extracellular matrix mucopolysaccharide hyaluronan, has been a key component of many important studies on embryonic and tumor-induced lymphangiogenesis, and continues to be used for the detection and isolation of lymphatic endothelial cells. However, LYVE-1 is interesting in its own right. Being a member of the Link protein family whose only other major hyaluronan receptor is directly involved in leukocyte migration and tumor metastasis, LYVE-1 is already implicated in the trafficking of cells within lymphatic vessels and lymph nodes. The current challenge is to determine the precise roles played by LYVE-1 and other scavenger type receptors in the immune functions of the lymphatics as well as to use LYVE-1 and other markers to investigate the way in which tumors exploit lymphatic vessels for metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.