|Tested species reactivity||Human|
|Published species reactivity||Not Applicable|
|Host / Isotype||Mouse / IgG2a, kappa|
|Immunogen||Purified human IgG myeloma proteins covalently coupled to polyaminostyrene micro beads|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Target||Lambda light chain|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:200|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-12410 targets Lambda Light Chain in IHC (P) applications and shows reactivity with Human samples.
The MA5-12410 immunogen is purified human IgG myeloma proteins covalently coupled to polyaminostyrene micro beads.
Antibody to the lambda light chain of immunoglobulin is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Chronic lymphocytic leukemia/small lymphocytic lymphoma: another neoplasm related to the B-cell follicle?
MA5-12410 was used in immunohistochemistry - paraffin section to investigate the B cell compartment of patients with chronic lymphocytic leukemia/small lymphocytic lymphoma.
|Tandon B,Swerdlow SH,Hasserjian RP,Surti U,Gibson SE||Leukemia and lymphoma (56:3378)||2015|
Liquid-based cytologic findings of solitary extramedullary plasmacytoma in thyroid: a case report identified with fine-needle aspiration cytology.
MA5-12410 was used in immunocytochemistry to report on a case of solitary extramedullary plasmacytoma of the thyroid
|Lee CH,Jung YY,Chung YR,Ryu HS||Diagnostic cytopathology (42:964)||2014|
Thyroid carcinoma-associated genetic mutations also occur in thyroid lymphomas.
MA5-12410 was used in immunohistochemistry to investigate the impact of mutations in BRAF, NRAS, HRAS, and KRAS on thyroid lymphomas
|Aggarwal N,Swerdlow SH,Kelly LM,Ogilvie JB,Nikiforova MN,Sathanoori M,Nikiforov YE||Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc (25:1203)||2012|
|Not Applicable||Not Cited||
Extramedullary plasmacytoma: clinicopathology, immunohistochemistry and therapeutic approach to a case with a tonsillar site.
MA5-12410 was used in immunohistochemistry to report a clinical case of extramedullary plasmacytoma
|Tokatli F,Puyan FO,Alas RC,Tuncbilek N,Uzal C||Hematology/oncology and stem cell therapy (1:241)||2010|