Invitrogen

Lamin A/C Polyclonal Antibody

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Lamin A/C Antibody in Immunocytochemistry (ICC/IF) — Immunocytochemistry analysis of Lamin A/C in A549 cells. Sample was incubated with Lamin A/C polyclonal antibody (Product # PA5-79605).

Lamin A/C Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry analysis of Lamin A/C on paraffin-embedded human mammary cancer tissue. Sample was incubated with Lamin A/C polyclonal antibody (Product# PA5-79605).

Lamin A/C Antibody in Western Blot (WB) — Western blot analysis of Lamin A/C in Lane 1: human placenta tissue lysate, Lane 2: SKOV whole cell lysate, Lane 3: SW620 whole cell lysate, Lane 4: COLO320 whole cell lysate, Lane 5: HeLa whole cell lysate, Lane 6: 293T whole cell lysate, Lane 7: A549 whole cell lysate using 40-50 µg per well. Sample was incubated with Lamin A/C (Product # PA5-79605) at a dilution of 0.5 µg/mL.

Product Details

PA5-79605

Applications	Tested Dilution	Publications
Western Blot (WB)	0.1-0.5 µg/mL	-
Immunohistochemistry (Paraffin) (IHC (P))	0.5-1 µg/mL	-
Immunocytochemistry (ICC/IF)	0.5-1 µg/mL	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	E.coli-derived human Lamin A/C recombinant protein (Position: Y481-Y646). View antigen
Conjugate	Unconjugated
Form	Lyophilized
Concentration	500 µg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS with 5mg BSA
Contains	0.05mg sodium azide
Storage conditions	-20°C
RRID	AB_2746720

Product Specific Information

Add 0.2 mL of distilled water, will yield a concentration of 500 µg/mL.

Target Information

Lamins are a class of intermediate filament proteins that form a matrix on the inner surface of the nuclear envelope. These proteins are found in many different cell types in three different forms (A, B, and C). Lamins A and C are alternatively spliced versions of the LMNA gene. The LMNA gene has been linked to many disorders of the muscular system, nervous system, and the fat distributions systems including: Emery-Dreifuss muscular dystrophy, Dunnigan-type familial partial lipodystrophy (FPLD), limb-girdle muscular dystrophy (LGMD1B), dilated cardiomyopathy (CMD1A), axonal neuropathy (Charcot-Marie-Tooth disease; CMT2B1), and mandibuloacral dysplasia (MAD).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 70 kDa lamin; lamin A; Lamin A+C mutant; lamin a-c; lamin A/C-like 1; Lamin AC; lamin C; lamin C2; Lamin-A/C; mutant 453W; Mutant lamin A/C; Prelamin-A/C; progerin mutant; Renal carcinoma antigen NY-REN-32; RP11-54H19.1

Gene Aliases: CDCD1; CDDC; CMD1A; CMT2B1; Dhe; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNA; LMNC; LMNL1; PRO1

UniProt ID: (Human) P02545, (Mouse) P48678

Entrez Gene ID: (Human) 4000, (Mouse) 16905, (Rat) 60374

Function(s)