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Invitrogen
Lamin A/C Monoclonal Antibody (131C3)
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FIGURE: 1 / 4
Lamin A/C Antibody (MA1-06102) in IHC (F)
Immunohistochemistry analysis of Lamin A-C in frozen sections of swine skin using a Lamin A/C Monoclonal Antibody (131C3) (Product # MA1-06102), showing strong positive staining in nuclei of the epidermal cells and to a lesser extent in the connective tissue. Dilution 1:500.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA1-06102
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Hamster,
Human,
Mouse,
Sheep,
Rat
Published species
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
131C3
Immunogen
Purified rat liver lamin.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
purified
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA1-06102 detects lamin A and C in human, mouse, rat, bovine, hamster, sheep, and canine samples.
MA1-06102 has sucessfully been used in immunocytochemistry, immunohistochemistry, FACs and Western blotting procedures.
The MA1-06102 immunogen is purified rat liver lamins.
MA1-06102 reacts with an epitope located between residues 319-566 in lamin A and C.
Target Information
Lamins are a class of intermediate filament proteins that form a matrix on the inner surface of the nuclear envelope. These proteins are found in many different cell types in three different forms (A, B, and C). Lamins A and C are alternatively spliced versions of the LMNA gene. The LMNA gene has been linked to many disorders of the muscular system, nervous system, and the fat distributions systems including: Emery-Dreifuss muscular dystrophy, Dunnigan-type familial partial lipodystrophy (FPLD), limb-girdle muscular dystrophy (LGMD1B), dilated cardiomyopathy (CMD1A), axonal neuropathy (Charcot-Marie-Tooth disease; CMT2B1), and mandibuloacral dysplasia (MAD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 70 kDa lamin; epididymis secretory sperm binding protein; lamin A; lamin A protein; Lamin A+C mutant; lamin a-c; lamin A/C; lamin A/C-like 1; Lamin AC; lamin C; lamin C protein; lamin C2; lamin-A/C; mandibuloacral dysplasia type A; mutant 453W; Mutant lamin A/C; nuclear envelope protein; prelamin-A/C; progerin; progerin mutant; renal carcinoma antigen NY-REN-32; RP11-54H19.1; unnamed protein product
Gene Aliases: CDCD1; CDDC; CMD1A; CMT2B1; Dhe; EMD2; FPL; FPLD; FPLD2; HGPS; I79_009616; IDC; Lamin-A/C; LDP1; LFP; LGMD1B; LMN1; LMNC; LMNL1; MADA; PRO1
UniProt ID: (Human) P02545, (Mouse) P48678
Entrez Gene ID: (Human) 4000, (Bovine) 404144, (Dog) 480124, (Sheep) 101107924, (Mouse) 16905, (Chinese hamster) 100757316, (Rat) 60374
double-strand break repair via nonhomologous end joining
protein import into nucleus
nucleus organization
nuclear envelope organization
nuclear migration
muscle organ development
protein localization
negative regulation of cell proliferation
positive regulation of gene expression
establishment of cell polarity
regulation of cell migration
establishment or maintenance of microtubule cytoskeleton polarity
heterochromatin assembly
regulation of protein stability
regulation of telomere maintenance
protein localization to nucleus
positive regulation of osteoblast differentiation
nuclear pore localization
ventricular cardiac muscle cell development
cellular response to hypoxia
negative regulation of mesenchymal cell proliferation
negative regulation of release of cytochrome c from mitochondria
cellular senescence
protein localization to nuclear envelope
regulation of protein localization to nucleus
negative regulation of cardiac muscle hypertrophy in response to stress
negative regulation of adipose tissue development
DNA double-strand break attachment to nuclear envelope
negative regulation of extrinsic apoptotic signaling pathway
spermatogenesis
response to mechanical stimulus
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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