This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Description: This 3A6-4C11 monoclonal antibody recognizes human and mouse Lamin A and Lamin C – two splice variants of the LMNA gene. The 3A6-4C11 antibody has been also reported to cross-react with rat Lamin A/C.
Applications Reported: This 3A6-4C11 antibody has been reported for use in western blotting and immunocytochemistry.
Applications Tested: This 3A6-4C11 antibody has been tested by western blotting of human and mouse cell line lysates. This may be used at 0.5 µg/mL.
Lamins are a class of intermediate filament proteins that form a matrix on the inner surface of the nuclear envelope. These proteins are found in many different cell types in three different forms (A, B, and C). Lamins A and C are alternatively spliced versions of the LMNA gene. The LMNA gene has been linked to many disorders of the muscular system, nervous system, and the fat distributions systems including: Emery-Dreifuss muscular dystrophy, Dunnigan-type familial partial lipodystrophy (FPLD), limb-girdle muscular dystrophy (LGMD1B), dilated cardiomyopathy (CMD1A), axonal neuropathy (Charcot-Marie-Tooth disease; CMT2B1), and mandibuloacral dysplasia (MAD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 70 kDa lamin; Lamin A+C mutant; lamin a-c; lamin A/C-like 1; Lamin AC; lamin C; Lamin-A/C; mutant 453W; Mutant lamin A/C; Prelamin-A/C; progerin mutant; Renal carcinoma antigen NY-REN-32; RP11-54H19.1
Gene Aliases: CDCD1; CDDC; CMD1A; CMT2B1; Dhe; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNA; LMNC; LMNL1; PRO1