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|Tested species reactivity||Bovine, Human, Rat|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Nuclear pore complex-lamina fraction of Xenopus laevis (XLKE-A6 cells)|
|Storage buffer||tissue culture supernatant|
|Contains||0.09% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||Assay Dependent|
|Western Blot (WB)||1:50|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 2 publications below|
MA1-5822 detects Lamin B1 & B2 in human, bovine, and rat samples, and Lamin B2 in mouse.
MA1-5822 has been successfully used in immunofluorescence and Western blot procedures.
The MA1-5822 immunogen is nuclear pore complex-lamina fraction of XLKE-A6 cells.
Store at 4°C of one month, or in small aliquots at -20°C for longer periods, avoiding freeze/thaw cycles.
This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
High expression of the cysteine proteinase legumain in colorectal cancer - implications for therapeutic targeting.
MA1-5822 was used in western blot to determine the subcellular expression and proteolytic activity patterns of legumain in tumor tissue
|Haugen MH,Boye K,Nesland JM,Pettersen SJ,Egeland EV,Tamhane T,Brix K,Maelandsmo GM,Flatmark K||European journal of cancer (Oxford, England : 1990) (51:9)||2015|
Association of nuclear-localized Nemo-like kinase with heat-shock protein 27 inhibits apoptosis in human breast cancer cells.
MA1-5822 was used in western blot to study the role of Hsp27 in the nuclear localization of NLK and consequent inhibition of breast cancer cell apoptosis
|Shaw-Hallgren G,Chmielarska Masoumi K,Zarrizi R,Hellman U,Karlsson P,Helou K,Massoumi R||PloS one (9:null)||2014|
B type lamin; lamin-B1
ADLD; BOS_7828; LMN; LMN2; LMNB; LMNB1