This antibody is predicted to react with mouse and rat based on sequence homology.
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Lamin B1 is one of the two B type proteins, B1.
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Protein Aliases: Lamin-B1; LMN2; LMNB; LMNB1
Gene Aliases: ADLD; LMN; LMN2; LMNB; LMNB1