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|Tested species reactivity||Mouse , Rat , Human , Chicken|
|Published species reactivity||Rat , Mouse , Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Extracts from chicken nuclei|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||0.1-1.0 ug/ml|
|Immunofluorescence (IF)||5-10 ug/ml|
|Immunoprecipitation (IP)||2.5-5 ug|
|Western Blot (WB)||0.5-1.0 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity.
33-2000 was used in western blot to investigate the effect of inositol polyphosphate-5-phosphatase F on STAT3 activity and gliomas tumorigenicity
|Kim HS,Li A,Ahn S,Song H,Zhang W||Scientific reports (4:null)||2014|
Immunoneutralization of endogenous aminoprocalcitonin attenuates sepsis-induced acute lung injury and mortality in rats.
33-2000 was used in western blot to investigate the role of aminoprocalcitonin in sepsis-induced acute lung injury and mortality in rats
|Tavares E,Maldonado R,Miñano FJ||The American journal of pathology (184:3069)||2014|
The piggyBac transposon displays local and distant reintegration preferences and can cause mutations at noncanonical integration sites.
33-2000 was used in western blot to identify the insertion site preferences of piggyBac.
|Li MA,Pettitt SJ,Eckert S,Ning Z,Rice S,Cadiñanos J,Yusa K,Conte N,Bradley A||Molecular and cellular biology (33:1317)||2013|
miR-218 directs a Wnt signaling circuit to promote differentiation of osteoblasts and osteomimicry of metastatic cancer cells.
33-2000 was used in western blot to study the miR-28/Wnt signaling in tumors.
|Hassan MQ,Maeda Y,Taipaleenmaki H,Zhang W,Jafferji M,Gordon JA,Li Z,Croce CM,van Wijnen AJ,Stein JL,Stein GS,Lian JB||The Journal of biological chemistry (287:42084)||2012|
Maxacalcitol ameliorates tubulointerstitial fibrosis in obstructed kidneys by recruiting PPM1A/VDR complex to pSmad3.
33-2000 was used in western blot to report a novel approach of inhibiting the TGF-β pathway to treat fibrotic diseases.
|Inoue K,Matsui I,Hamano T,Fujii N,Shimomura A,Nakano C,Kusunoki Y,Takabatake Y,Hirata M,Nishiyama A,Tsubakihara Y,Isaka Y,Rakugi H||Laboratory investigation; a journal of technical methods and pathology (92:1686)||2012|
The imprinted NPAP1/C15orf2 gene in the Prader-Willi syndrome region encodes a nuclear pore complex associated protein.
33-2000 was used in western blot to test if C5orf2 is located at nuclear pores.
|Neumann LC,Markaki Y,Mladenov E,Hoffmann D,Buiting K,Horsthemke B||Human molecular genetics (21:4038)||2012|
Protection against 2-chloroethyl ethyl sulfide (CEES)-induced cytotoxicity in human keratinocytes by an inducer of the glutathione detoxification pathway.
33-2000 was used in western blot to search for chemopreventive agent for sulfur mustard toxicity in the skin.
|Abel EL,Bubel JD,Simper MS,Powell L,McClellan SA,Andreeff M,MacLeod MC,DiGiovanni J||Toxicology and applied pharmacology (255:176)||2011|
JNJ-26481585, a novel "second-generation" oral histone deacetylase inhibitor, shows broad-spectrum preclinical antitumoral activity.
||Arts J,King P,Mariën A,Floren W,Beliën A,Janssen L,Pilatte I,Roux B,Decrane L,Gilissen R,Hickson I,Vreys V,Cox E,Bol K,Talloen W,Goris I,Andries L,Du Jardin M,Janicot M,Page M,van Emelen K,Angibaud P||Clinical cancer research : an official journal of the American Association for Cancer Research (15:6841)||2009|
Point mutation in AML1 disrupts subnuclear targeting, prevents myeloid differentiation, and effects a transformation-like phenotype.
||Vradii D,Zaidi SK,Lian JB,van Wijnen AJ,Stein JL,Stein GS||Proceedings of the National Academy of Sciences of the United States of America (102:7174)||2005|
Two distinct Fas-activated signaling pathways revealed by an antitumor drug D609.
||Zhang L,Shimizu S,Tsujimoto Y||Oncogene (24:2954)||2005|
Growth differentiation factor-5 promotes brown adipogenesis in systemic energy expenditure.
||Hinoi E,Nakamura Y,Takada S,Fujita H,Iezaki T,Hashizume S,Takahashi S,Odaka Y,Watanabe T,Yoneda Y||Diabetes (63:162)||2014|
LMN2, LMNB, ADLD, LMN
lamin-B1, ADLD, LMN, LMN2, LMNB