Recommended positive controls: A431, H1299, HeLa, NIH-3T3.
Predicted reactivity: Mouse (88%), Bovine (89%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Laminins are large heterotrimeric, noncollagenous glycoproteins composed of alpha, beta, and gamma chains. They are ubiquitously present in basement membrane (BM) along with entactin/nidogen (EN), collagen type IV (CIV), and large heparan sulfate proteoglycan (HSPG), which interact specifically with each other to form a continuous and regular BM. Alterations of BM integrity, from local discontinuities up to complete loss, are described in many types of human and animal epithelial neoplasms.
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Protein Aliases: Laminin B1 chain; laminin B1 subunit 1; laminin beta 1; Laminin subunit beta-1; laminin, beta 1; Laminin-1 subunit beta; Laminin-10 subunit beta; Laminin-12 subunit beta; Laminin-2 subunit beta; Laminin-6 subunit beta; Laminin-8 subunit beta; MGC142015
Gene Aliases: C77966; C80098; C81607; CLM; D130003D08Rik; Lamb-1; LAMB1; Lamb1-1; LIS5
Molecular Function: extracellular matrix protein