MA5-11992 targets Laminin B2/gamma1 in IHC (P) applications and shows reactivity with Guinea Pig, Human, and Rat samples.
The MA5-11992 immunogen is rat glomerular basement membrane.
Laminins are large heterotrimeric, noncollagenous glycoproteins composed of alpha, beta, and gamma chains. They are ubiquitously present in basement membrane (BM) along with entactin/nidogen (EN), collagen type IV (CIV), and large heparan sulfate proteoglycan (HSPG), which interact specifically with each other to form a continuous and regular BM. Alterations of BM integrity, from local discontinuities up to complete loss, are described in many types of human and animal epithelial neoplasms.
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Protein Aliases: Laminin B1s chain; Laminin B2 chain; laminin S; Laminin subunit beta-2; Laminin subunit gamma-1; laminin, beta 2 (laminin S); laminin, gamma 1 (formerly LAMB2); Laminin-1 subunit gamma; Laminin-10 subunit gamma; Laminin-11 subunit beta; Laminin-11 subunit gamma; Laminin-14 subunit beta; Laminin-15 subunit beta; Laminin-2 subunit gamma; Laminin-3 subunit beta; Laminin-3 subunit gamma; Laminin-4 subunit beta; Laminin-4 subunit gamma; Laminin-6 subunit gamma; Laminin-7 subunit beta; Laminin-7 subunit gamma; Laminin-8 subunit gamma; Laminin-9 subunit beta; Laminin-9 subunit gamma; S-LAM beta; S-LAM gamma; S-laminin subunit beta; S-laminin subunit gamma
Gene Aliases: LAMB2; LAMC1; LAMS; NPHS5