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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 58 and 287 of Human Langerin|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-30722 targets Langerin in WB applications and shows reactivity with Human samples.
The PA5-30722 immunogen is recombinant protein fragment corresponding to a region within amino acids 58 and 287 of Human Langerin.
The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
C-type lectin domain family 4; C-type lectin domain family 4, member K; CD207 antigen; CD207 antigen, langerin; CD207 molecule, langerin; CLEC4K; Langerhans cell specific c-type lectin; langerin; member K