LH is a member of the glycoprotein hormone family, Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism.
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Protein Aliases: Anterior pituitary glycoprotein hormones common subunit alpha; CG-alpha; Choriogonadotropin alpha chain; Chorionic gonadotrophin subunit alpha; chorionic gonadotropin, alpha polypeptide; Follicle-stimulating hormone alpha chain; follicle-stimulating hormone alpha subunit; follitropin; Follitropin alpha chain; FSH-alpha; FSH-beta; Glycoprotein hormones alpha chain; glycoprotein hormones, alpha subunit; hLHB; interstitial cell stimulating hormone, beta chain; leutropin; LH-B; LSH-alpha; LSH-B; LSH-beta; Luteinizing hormone (lutropin) subunit beta; Luteinizing hormone alpha chain; luteinizing hormone beta subunit; Luteinizing hormone subunit beta; Lutropin alpha chain; Lutropin beta chain; Lutropin subunit beta; pituitary hormone alpha subunit; Thyroid-stimulating hormone alpha chain; Thyrotropin alpha chain; TSH-alpha
Gene Aliases: aGSU; alpha-GSU; alphaGSU; alphaSU; CG-ALPHA; CGA; Cga1; CGB4; FSHA; GPHa; GPHA1; GPHalpha; HCG; HH23; LH; LH-B; LHA; LHB; LSH-B; LSH-beta; TSHA