Ly49 receptors exhibit allelic specificity for MHC class I Ia molecules and are thought to serve to prevent natural killer (NK) cells from attacking normal cells, while allowing them to attack infected or transformed cells in which class I molecules have been down-regulated. These inhibitory receptors are also expressed on subpopulations of mouse CD8+ T cells.
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Protein Aliases: 5E6; Killer cell lectin-like receptor 3; killer cell lectin-like receptor subfamily A, member 9; Ly-49; Ly-49c; Ly-49I receptor; Ly49I receptor; Lymphocyte antigen 49c; Nk2.1; T-cell surface glycoprotein Ly-49C
Gene Aliases: Klra3; Ly-49c; Ly49C; Ly49I; LY49I1
UniProt ID: (Mouse) Q64329
Entrez Gene ID: (Mouse) 16640