|Tested species reactivity||Bovine, Human, Mouse, Pig, Rat|
|Published species reactivity||Not Applicable|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Cocktail of two synthetic peptides between amino acids 300-350 and amino acids 200-300 of the human LOX protein.|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:200|
|Western Blot (WB)||1:1000-1:5000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
This antibody is 92% homologous to chicken, zebrafish, and xenopus.
Lysyl oxidase (LOX), a copper-containing amine oxidase, belongs to a heterogeneous family of enzymes that oxidize primary amine substrates to reactive aldehydes. It plays a vital role in the formation and repair of the extra cellular matrix. As well, LOX is a multifunctional enzyme having diverse biological functions such as developmental regulation, tumor suppression, cell motility and cellular senescence. The secreted form of LOX is responsible for the invasive properties of hypoxic human cancer cells. Thus, it is essential for hypoxia-induced metastasis and is a good therapeutic target for preventing and treating metastases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Not Applicable||Not Cited||
Upregulated copper transporters in hypoxia-induced pulmonary hypertension.
PA1-16955 was used in western blot to research hypoxia-induced pulmonary hypertension and upregulation in copper transporters
|Zimnicka AM,Tang H,Guo Q,Kuhr FK,Oh MJ,Wan J,Chen J,Smith KA,Fraidenburg DR,Choudhury MS,Levitan I,Machado RF,Kaplan JH,Yuan JX||PloS one (9:null)||2014|