|Immunofluorescence (IF)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Tested Species reactivity||Human|
|Host / Isotype||Rat / IgG1, kappa|
|Immunogen||A v-ras-transformed rat NRK cells expressing transduced human CSF-1R|
|Purification||Ammonium sulfate precipitation|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage conditions||4° C|
MA5-14627 targets CD115 in IF and IHC (F) applications and shows reactivity with Human samples.
The MA5-14627 immunogen is a v-ras-transformed rat NRK cells expressing transduced human CSF-1R.
CD115, also known as c-fms, macrophage Colony Stimulating Factor Receptor (M-CSFR), or CSF-1R, exists in immature (gp130c-fms) and mature (gp150c-fms) forms. CSF-1R exhibits an intrinsic tyrosine-specific protein kinase activity. It is expressed on the cells of the mononuclear phagocyte lineage. CSF-1R is an integral transmembrane glycoprotein consisting of a 512 amino acid extracellular domain that includes the CSF-1 binding site, a single 25 amino acid membrane-spanning segment, and a 435 amino acid cytoplasmic portion that includes the tyrosine kinase domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C-FMS; CD115; CD115 antigen; colony stimulating factor 1 receptor; CSF-1 receptor; CSF1R; CSFR; FIM2; FMS; FMS proto-oncogene; macrophage colony stimulating factor I receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog; McDonough feline sarcoma viral v-fms oncogene homolog; proto-oncogene c-Fms
Gene Aliases: C-FMS; CD115; CSF-1R; CSFR; FIM2; FMS; HDLS; M-CSF-R
UniProt ID: (Human) P07333
Entrez Gene ID: (Human) 1436
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