|Tested species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Recombinant protein fragment, corresponding to the extracellular domain of human MCSF receptor.|
|Purification||Antigen affinity chromatography|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|ELISA (ELISA)||0.5-1 µg/ml|
|Western Blot (WB)||0.1-0.2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-20183 detects MCSF Receptor in human samples.
PA1-20183 has been successfully used in ELISA and Western blot procedures.
The PA1-20183 immunogen corresponds to a recombinant fragment corresponding to the extracellular domain of human MCSF receptor.
Macrophage Colony Stimulating Factor Receptor is the homodimeric product of the c-fms proto oncogene and maps to chromosome 5 at band 5q33.3. It is a member of the type III subfamily of receptor tyrosine kinases. Other members of this subfamily include Flt-3, the receptor for SCF, and the alpha and beta receptors for PDGF. These receptors are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. MCSF binding induces receptor homodimerization, resulting in transphosphorylation of specific cytoplasmic tyrosine residues and signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein metabolism and modification Protein modification Protein phosphorylation Signal transduction Cell surface receptor mediated signal transduction Receptor protein tyrosine kinase signaling pathway Immunity and defense Stress response Oncogenesis Developmental processes Gametogenesis Embryogenesis Cell structure and motility Cell motility Cell proliferation and differentiation