Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
MA1-20102 detects PR3 in human samples.
MA1-20102 has been successfully used in ELISA procedures.
The MA1-20102 immunogen is human proteinase PR3 purified leukocyte mass.
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AGP7; azurophil granule protein 7; C-ANCA antigen; Leukocyte proteinase 3; Myeloblastin; Neutrophil proteinase 4; NP-4; P29; PR-3; serine proteinase, neutrophil; Wegener autoantigen; Wegener granulomatosis autoantigen
Gene Aliases: MBN; PRTN3
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