MA1-21672 detects Thyroglobulin in Human and Bovine samples.
MA1-21672 has been successfully used in ELISA procedures.
MA1-21672 immunogen corresponds to Thyroglobulin from human thyroid gland.
The human thyroglobulin (hTg) is a high molecular weight glycoprotein (605 kDa) found in the thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones, T4 and T3. Thyroid disorders are, in large part, due to autoimmune origin, and anti-thyroglobulin autoantibodies were the first factor to be discovered. Anti-hTG is found in all thyroid autoimmune diseases (Hashimotoís thyroiditis, Gravesí diseases), with the highest level observed in Hashimotoís thyroiditis. Anti-hTG is also characteristic of thyroid cancer, and its determination can be used for the follow up of cancer patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AITD3; hereditary goitre; Tg; TGN; Thyroglobulin
Gene Aliases: AITD3; TG; TGN