CD25 (IL2 receptor alpha chain/IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2RA) is a heterotrimeric protein complex with a gamma chain also shared by interleukin 4 (IL4) and interleukin 7 (IL7). IL2RA, IL2R beta chain (IL2RB), and the IL2R gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric IL2RA chains result in low-affinity receptor, while homodimeric IL2RB chains produce a medium-affinity receptor. The expression of IL2 in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. IL2 is primarily produced by mature T cells. IL2 plays an important role as a growth factor, differentiation factor, and regulator of cell death. IL-2 stimulates the proliferation of B cells, augments natural killer cell activity, and inhibits granulocyte macrophage colony formation. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests a role in the immune response to antigenic stimuli. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
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Protein Aliases: CD25; CD25 antigen; cytokine receptor; IL-2 Receptor alpha chain; IL-2 receptor alpha subunit; IL-2 receptor subunit alpha; IL-2-RA; IL-2R alpha; IL-2R alpha chain; IL-2R subunit alpha; IL2 RA antibody; IL2-RA; Il2ra antibody; interleukin 2 receptor alpha chain; Interleukin 2 receptor alpha chain antibody; interleukin 2 receptor, alpha; interleukin 2 receptor, alpha chain; interleukin-2 receptor alpha chain; Interleukin-2 receptor subunit alpha; p55; p55 chain; TAC antigen; TAC antigen antibody
Gene Aliases: BOS_12822; CD25; IDDM10; IL-2RA; IL2R; IL2RA; IL2RAC; IMD41; Ly-43; p55; TCGFR