MA1-40046 detects C3 from mouse samples.
MA1-40046 has been successfully used in flow cytometry, immunohistochemistry (frozen, paraffin), ELISA, immunofluorescence, immunoprecipitation, and Western blot applications.
ELISA: Antibody was used as coating 0.5 µg/well in PBS.
The MA1-40046 immunogen is mouse C3 acute phase protein.
The complement factor C3 consists of an alpha- and a beta-chain. C3 is a central factor in the complement cascade. It is central to the alternative pathway that leads to the C3 convertase C3bBb. The classical and mannose binding lectin activation pathways lead to the C3 convertase C4b2a. These convertases cleave C3 resulting in C3a and C3b. Further degradation leads to formation of the alpha-chain products C3d, C3g and C3c. The monoclonal antibody 11H9 reacts with C3, C3b, iC3b and C3d. C3 is an acute phase protein that is produced by a wide range of tissues including renal epithelial cells and hepatocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Acylation stimulating protein; ASP; C3-beta-c; C3a anaphylatoxin; C3adesArg; C3bc; Complement C3; Complement C3 alpha chain; Complement C3 beta chain; Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3c alpha' chain fragment 2; Complement C3d fragment; Complement C3dg fragment; Complement C3f fragment; Complement C3g fragment; Complement component 3; HSE-MSF
Gene Aliases: AI255234; ASP; C3; HSE-MSF; Plp
UniProt ID: (Mouse) P01027
Entrez Gene ID: (Mouse) 12266