MA1-5763 detects the 64k basic keratin K3 in human, rabbit, rat and bovine samples.
MA1-5763 has been successfully used in Western blot, immunocytochemistry/immunofluorescence and immunohistochemistry (paraffin) procedures.
The MA1-5763 immunogen is Rabbit corneal epithelial keratins.
Cytokeratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. Cutokeratin 8 typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 65 kDa cytokeratin; CK-3; cytokeratin 3; cytokeratin type II, component Ib/c; Cytokeratin-3; K3; K3 keratin; keratin 3, type II; keratin K3; Keratin, type II cytoskeletal 3; Keratin-3; Type-II keratin Kb3
Gene Aliases: CK-3; CK3; K3; KERIB; KRT3
UniProt ID: (Human) P12035