MA1-5763 detects the 64k basic keratin K3 in human, rabbit, rat and bovine samples.
MA1-5763 has been successfully used in Western blot, immunocytochemistry/immunofluorescence and immunohistochemistry (paraffin) procedures.
The MA1-5763 immunogen is Rabbit corneal epithelial keratins.
Cytokeratins, a group comprising at least 29 different proteins, are characteristic of epithelial and trichocytic cells. Cytokeratin 5, 6 and 8 are members of the type II neutral-to-basic subfamily. Monoclonal antibodies to cytokeratins are specific markers of epithelial cell differentiation and have been widely used as tools in tumor identification and classification. PCK-26 facilitates the typing of normal, metaplastic and neoplastic cells and it may aid in the discrimination of carcinomas and non-epithelial tumors such as sarcomas, lymphomas and neural tumors. It is also useful in detecting micro-metastases in lymph nodes and other tissues and for determining the origin of poorly differentiated tumors (1,2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 65 kDa cytokeratin; CK-3; cytokeratin 3; Cytokeratin-3; K3; K3 keratin; keratin 3; keratin 3, type II; keratin K3; Keratin, type II cytoskeletal 3; Keratin-3; Type-II keratin Kb3
Gene Aliases: CK-3; CK3; K3; KERIB; KRT3