MA1-70060 detects C5a receptor in human samples.
MA1-70060 has been successfully used in flow cytometry and immunohistochemistry (frozen sections) procedures.
The MA1-70060 immunogen is RBL-2H3 (rat basophilic leukemia) transfected cells expressing human C5aR on the cell surface.
C5AR1 is an C5a Anaphylatoxin Receptor that mediates the effects of one of the most potent chemotactic agents known. C5AR1 has been implicated in asthma, and its expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract. C5AR1 is the receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Functionally, C5AR1 stimulates chemotaxis, granule enzyme release and superoxide anion production. C5a is likely a component of the classical pathway of the complement cascade; it may be involved with tissue injury associated with ischemia or sepsis and it may be a component of the membrane attack complex. Diseases associated with C5AR1 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C5A; C5a anaphylatoxin chemotactic receptor; C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin receptor; C5a ligand; C5a Receptor; C5a-R; C5AR; C5R1; CD88; complement component 5 receptor 1
Gene Aliases: C5A; C5AR; C5AR1; C5R1; CD88
UniProt ID: (Human) P21730
Entrez Gene ID: (Human) 728