This antibody is specific for RIZ1, it does not recognize the isoform beta (RIZ2).
PRDM2, a member of nuclear/histone methyltransferase superfamily, consists of an N-terminal PR domain, an Rb-binding motif, 8 Kruppel-like zinc finger motifs, Nuclear hormone-receptor binding motif and a C-terminal PR-domain binding motif. Ubiquitously expressed in low levels, PRDM2 exists in 2 isoforms, a 280 kDa RIZ1 containing PR-domain and a 250 kDa truncated RIZ2 that lacks PR-domain. A tumor suppressor with a prominent role in cell growth and differentiation, PRDM2 binds to Retinoblastoma protein, estrogen receptor, GATA-3 and TPA-responsive element (MTE) of Heme-oxygenase-1 gene and influences pathogenesis of Retinoblastoma, transcriptional regulation during neuronal differentiation, transactivation of Heme-oxygenase-1 gene and specific effector of estrogen action. It is inactivated or altered due to mutations and hypermethylation in many types of human cancers suggesting a potential biomarker.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: G3b; GATA-3 binding protein G3B; GATA-3-binding protein G3B; Lysine N-methyltransferase 8; MTB-ZF; MTBzf; MTE-binding protein; PR domain containing 2, with ZNF domain; PR domain zinc finger protein 2; PR domain-containing protein 2; retinoblastoma protein-binding zinc finger protein; Retinoblastoma protein-interacting zinc finger protein; RP5-1177E19.1; Zinc finger protein RIZ; zinc-finger DNA-binding protein
Gene Aliases: 4833427P12Rik; E330024L24Rik; Gm1033; Gm19732; HUMHOXY1; KMT8; MTB-ZF; PRDM2; RIZ; RIZ1; RIZ2; Znfpr1c1
UniProt ID: (Human) Q13029
Molecular Function: C2H2 zinc finger transcription factor