MA5-13365 targets Renal Cell Carcinoma Marker in IHC (P) and WB applications and shows reactivity with Human and Rat samples.
The MA5-13365 immunogen is microsomal fraction of human renal cortical tissue homogenate.
CD205 (LY25, Lymphocyte Antigen 75) is an integral membrane glycoprotein involved in antigen uptake, trafficking and presentation that improves the induction of antigen-specific T cell immunity. CD205 is highly expressed by CD8+ dendritic cells (DCs) and also expressed at different levels by bone marrow Gr1+ cells, Langerhans cells, (BMDC) bone marrow derived DCs and thymic epithelial cells. CD205 acts as an endocytic receptor that directs captured antigens to the extracellular space towards a specialized antigen processing region. Further, CD205 also prompts the reduced proliferation of B lymphocytes. Diseases associated with CD205 dysfunction include pneumonic plague and lipid pneumonia.
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Protein Aliases: C-type lectin domain family 13 member B; carbonate dehydratase IX; carbonic anhydrase 9; carbonic dehydratase; CD205; DEC-205; gp200-MR6; Ly-75; Lymphocyte antigen 75; membrane antigen MN; RCC-associated protein G250; renal cell carcinoma-associated antigen G250
Gene Aliases: CD205; CLEC13B; DEC-205; GP200-MR6; LY-75; LY75; RGD1565962
UniProt ID: (Human) O60449
Molecular Function: receptor