MA5-14663 targets Alpha2-Macroglobulin in ELISA, IP, and RIA applications and shows reactivity with Human samples.
The MA5-14663 immunogen is purified human plasma AMG.
MA5-14663 detects Alpha2-Macroglobulin which has a predicted molecular weight of approximately 162 kDa.
Product MA514663 is a smaller package size of MIA1201 (formerly sold as a Seradyn product).
Alpha 2-Macroglobulin (a2M), is a approximately 720-kDa homotetrameric glycoprotein composed of four identical approximately 180 kDa subunits. aAlpha 2M shares with other alpha-macroglobulins, like the complement components C3 and C4 and the pregnancy zone protein PZP, an extraordinary binding capacity for a variety of ligands. This allows the alpha-macroglobulins to serve as humoral defense barriers against foreign peptides in the plasma. Alpha 2M interacts and captures virtually any proteinase, often referred to as a panprotease inhibitor. In the brain of Alzheimer's disease (AD) patients, Alpha 2M also has been localized to diffuse amyloid plaques, supporting an important role for alpha 2M in AD etiopathology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Alpha 2 M; Alpha-2-M; Alpha-2-macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; DKFZp779B086; S863 7
Gene Aliases: A2M; A2MD; CPAMD5; FWP007; S863-7
UniProt ID: (Human) P01023
Entrez Gene ID: (Human) 2
Molecular Function: protease inhibitor