This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
It is not recommended to aliquot this antibody.
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 4E-BP1; eIF4E-binding protein 1; Eukaryotic translation initiation factor 4E-binding protein 1; PHAS-I; Phosphorylated heat- and acid-stable protein regulated by insulin 1
Gene Aliases: 4E-BP1; 4EBP1; AA959816; BP-1; EIF4EBP1; PHAS-I