MA5-15434 targets AXL in WB applications and shows reactivity with Human samples.
The MA5-15434 immunogen is purified recombinant fragment of AXL(aa466-530) expressed in E. Coli.
The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.
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Protein Aliases: AXL; AXL oncogene; AXL transforming sequence/gene; JTK11; Tyrosine-protein kinase receptor UFO; UFO
Gene Aliases: ARK; AXL; JTK11; Tyro7; UFO
UniProt ID: (Human) P30530
Entrez Gene ID: (Human) 558