MA5-15482 targets CHIT1 in WB applications and shows reactivity with Human samples.
The MA5-15482 immunogen is purified recombinant fragment of CHIT1 (aa22-137) expressed in E. Coli.
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens.
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Protein Aliases: chitinase 1 (chitotriosidase); Chitinase-1; Chitotriosidase; Chitotriosidase-1; EC 126.96.36.199; FLJ00314; MGC125322; plasma methylumbelliferyl tetra-N-acetylchitotetraoside hydrolase
Gene Aliases: CHI3; CHIT; CHIT1; CHITD
UniProt ID: (Human) Q13231
Entrez Gene ID: (Human) 1118