MA5-15831 targets CTTN in IHC and WB applications and shows reactivity with Human and mouse samples.\r
The MA5-15831 immunogen is purified recombinant fragment of human CTTN expressed in E. Coli. .\r
MA5-15831 detects CTTN which has a predicted molecular weight of approximately 80kDa.
Cortactin (Cttn) is a ubiquitous actin-binding protein that was originally identified as a substrate for Src. It contributes to the organization of the actin cytoskeleton and cell shape. Cortactin also plays a role in the formation of lamellipodia and cell migration. It is accumulated in peripheral, actin-enriched structures of cells suggesting that cortactin facilitates actin network formation. Cortactin has four major domains of interest the N-terminal acidic (NTA) and tandem repeats domains and the C-terminal proline-rich and SH3 Domains. NTA associates with the Arp2/3 and WASP complex at F-actin branches. Cortactin is involved in promoting cell motility and invasion, including a critical role in invadopodia, actin rich-subcellular protrusions associated with degradation of the ECM by cancer cells. Cortactin is phosphorylated by src family kinases at Y421, Y466, and Y482 and S405 and S418 that are phosphorylated by Erk family kinases.
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Protein Aliases: 1110020L01Rik; Amplaxin; ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate); FLJ34459; mammary tumor and squamous cell carcinoma associated (p80/85 src substrate); Oncogene EMS1; Oncogene SRC8; Src substrate cortactin; src8
Gene Aliases: 1110020L01Rik; CTTN; EMS1