The T cell antigen receptor (TCR) consists of a ligand-specific alpha/beta heterodimer non-covalently associated with five invariant chains including the CD3 gamma/delta/eta and zeta subunits, all of which are required for efficient surface expression. T cell activation through the TCR induces cellular differentiation and/or proliferation and the production of lymphokines and cytokines. Both the CD3 and TCR zeta subunits are proposed to be responsible for the intracellular signal transduction events.
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Protein Aliases: alpha polypeptide; FLJ22602; MGC117436; MGC22624; MGC23964; MGC71411; T-cell antigen receptor; T-cell receptor; TCR beta; TCRA; Tcrb; TCRD; TRA
Gene Aliases: TCRbeta; Tib
Entrez Gene ID: (Mouse) 21577