|Flow Cytometry (Flow)||1 µg /1x10^6 cells|
|Host / Isotype||Rat / IgG2a, kappa|
|Immunogen||Murine T cell clone AE7 cells|
|Excitation/Emission Profile||View spectra|
|Storage buffer||PBS with 4-5mg/mL BSA|
|Contains||0.02% sodium azide|
|Storage conditions||4° C, do not freeze|
MA5-17958 targets TIM3 in FACS and WB applications and shows reactivity with Mouse samples.
The MA5-17958 immunogen is mouse T cell clone AE7 cells.
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ14428; HAVcr-2; HAVCR2; hepatitis A virus cellular receptor 2; Hepatitis A virus cellular receptor 2 homolog; kidney injury molecule 6; KIM-3; T cell immunoglobulin mucin 3; T-cell immunoglobulin and mucin domain containing 3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; TIM-3; TIMD-3; TIMD3
Gene Aliases: Havcr2; TIM-3; Tim3; Timd3
UniProt ID: (Mouse) Q8VIM0
Entrez Gene ID: (Mouse) 171285
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