Peptide Sequence: MAEPGEGLPE EVLALIFRHL SLRDRAAAAR VCRAWAAAAT CSAVWHDTKI SCECELEGML PPYLSACLDH IHNLRLEFEP SRKPSRRAAI ELLMVLAGRA PGLRGLRLEC RGEKPLFDAG RDVLEAVHAV CGAASQLRHL DLRRLSFTLD DALVLQAARS CPELHSLFLD NSTLVGSVGP GSVLELLEAC PRLRALGLHL ASLSHAILEA LAAPDRAPFA LLALRCACPE DARASPLPNE AWVALRRRHP GLAVELELEP ALPAESVTRV LQPAVPVAAL RLNLSGDTVG PVRFAAHHYA ATLCALEVRA AASAELNAAL EELAARCAAL REVHCFCVVS HSVLDAFRAH CPRLRTYTLK LTREPHPWRP TLVA
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. It shares 78% sequence identity with the mouse protein.
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