|Flow Cytometry (Flow)||0.25 µg/1x10^6 cells|
|Immunohistochemistry (Frozen) (IHC (F))||8-25 µg/mL|
|Western Blot (WB)||1 µg/mL|
|Species reactivity||Human, Mouse|
|Host / Isotype||Rat / IgG2A|
|Immunogen||Mouse myeloma cell line NS0-derived recombinant human Cadherin-13 Glu23-Ala692|
|Storage buffer||PBS with 5% trehalose|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) E-Cadherin, rhN-Cadherin, rhP-Cadherin, rhVE-Cadherin, rhCadherin-8, -11, -12 or -17 is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
The cadherins are a family of Ca++-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including beta-catenin, to regulate cadherin function. T-cadherin (for truncated-cadherin, also designated heartcadherin or cadherin-13) expression levels have been shown to be reduced in human breast cancers and carcinoma cells lines. Evidence suggests that.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CAD13; cadherin 13, H-cadherin (heart); Cadherin-13; CDH13; CDHH; H-cadherin; H-cadherin (heart); Heart Cadherin; P105; T cad; T Cadherin; T-cad; T-cadherin; Truncated Cadherin
Gene Aliases: 4932416G01Rik; CDH13; CDHH; Cdht; P105; T-cadherin; Tcad
Molecular Function: cadherin
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.