This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry.
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Protein Aliases: BMP antagonist 3; CER2CRL2; Cerberus 2; Cerberus like-2; cerberus-like 2; Cerberus-like protein 2; Cerl-2; CERL2; CKTSF1B3; CKTSF1B3MGC126849; COCO; Cysteine knot superfamily 1; Cysteine knot superfamily 1, BMP antagonist 3; DAN domain family; DAN domain family member 5; DAN domain family member 5, BMP antagonist; DAN domain family, member 5; DAND5; DANTE; DTE; FLJ38607; GREM3; GREM3cerberus 2; Gremlin-3; member 5; SP1
Gene Aliases: CER2; CERL2; CKTSF1B3; COCO; CRL2; DAND5; DANTE; GREM3; SP1
UniProt ID: (Human) Q8N907
Entrez Gene ID: (Human) 199699