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Peptide Sequence: LHRDFCDLKE NNYKGITAKP VSEDMMEWEV EIEGLQNSVW QGLVFQLTIH FTSEYNYAPP VVKFITIPFH PNVDPHTGQP CIDFLDNPEK WNTN
The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. The first step requires ATP-dependent activation of the Ub C-terminus and assembly of multi-Ub chains by a Ub-activating enzyme known as the E1 component. The Ub chain is then conjugated to the Ub-conjugating enzyme (E2) to generate an intermediate Ub-E2 complex. The Ub-ligase (E3) then catalyzes the transfer of Ub from E2 to the appropriate protein substrate. UBE2U (ubiquitin-conjugating enzyme E2U) is a 321 amino acid E2 ubiquitin conjugating enzyme that catalyzes the covalent attachment of ubiquitin to other proteins. Existing as two alternatively spliced isoforms, UBE2U is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: E2 ubiquitin-conjugating enzyme U; MGC35130; RP4-636O23.1; testicular tissue protein Li 216; Ubiquitin carrier protein U; ubiquitin conjugating enzyme E2U (putative); Ubiquitin-conjugating enzyme E2 U; ubiquitin-conjugating enzyme E2U (putative); Ubiquitin-protein ligase U
Gene Aliases: UBE2U
UniProt ID: (Human) Q5VVX9
Entrez Gene ID: (Human) 148581
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