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In Western blots, approximately 25% cross-reactivity with recombinant mouse IL-17B is observed and no cross-reactivity with recombinant human (rh) IL-17, rhIL-17C, rhIL-17E or rhIL-17F is observed.
The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies.
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Protein Aliases: Cytokine Zcyto7; cytokine-like protein ZCYTO7; IL-17B; IL-20; interleukin 20; interleukin-17 beta; Interleukin-17B; Interleukin-20; Interleukin20; neuronal interleukin-17 related factor; Neuronal interleukin-17-related factor
Gene Aliases: IL17B; IL20; NIRF; UNQ516/PRO1031; ZCYTO7
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