Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). An important group of antigens is coded by the MAGE family of genes. It was identified that melanoma associated with antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various hisological tyoes (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.
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Protein Aliases: Antigen MZ2-E; Cancer/testis antigen 1.1; cancer/testis antigen family 1, member 1; CT1.1; mage 1; mage-1; MAGE-1 antigen; melanoma antigen family A 1; melanoma antigen family A, 1 (directs expression of antigen MZ2-E); melanoma antigen family A1; melanoma antigen MAGE-1; Melanoma-associated antigen 1; melanoma-associated antigen MZ2-E
Gene Aliases: CT1.1; MAGE1; MAGE1A; MAGEA1
UniProt ID: (Human) P43355
Entrez Gene ID: (Human) 4100
Molecular Function: cell adhesion molecule