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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Full length recombinant human MAGE-1 protein|
|Storage buffer||tissue culture supernatant|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:20|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-12477 targets MAGE-1 in IHC (P) applications and shows reactivity with Human samples.
The MA5-12477 immunogen is full length recombinant human MAGE-1 protein.
Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor-directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). An important group of antigens is coded by the MAGE family of genes. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
antigen MZ2-E; cancer/testis antigen 1.1; cancer/testis antigen family 1; cancer/testis antigen family 1, member 1; MAGE-1 antigen; melanoma antigen family A 1; melanoma antigen family A, 1 (directs expression of antigen MZ2-E); melanoma antigen family A1; melanoma antigen MAGE-1; melanoma-associated antigen 1; melanoma-associated antigen MZ2-E; member 1
CT1.1; MAGE1; MAGE1A; MAGEA1