MA5-11338 targets MAGE-1 in IF, IHC (P), and WB applications and shows reactivity with Canine, Human, and Rat samples.
The MA5-11338 immunogen is partially purified, full length recombinant human MAGE-1 protein.
Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). An important group of antigens is coded by the MAGE family of genes. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Antigen MZ2-E; Cancer/testis antigen 1.1; cancer/testis antigen family 1; cancer/testis antigen family 1, member 1; CT1.1; MAGE-1 antigen; melanoma antigen family A 1; melanoma antigen family A, 1 (directs expression of antigen MZ2-E); melanoma antigen family A1; melanoma antigen MAGE-1; Melanoma-associated antigen 1; melanoma-associated antigen MZ2-E; melanotransferrin; member 1
Gene Aliases: CT1.1; MAGE1; MAGE1A; MAGEA1
UniProt ID: (Human) P43355