Positive test controls include: NCI-H460, OVCAR3, HepG2, 293T, Rat lung. The target is usually found in the following locations: Cytoplasm, Cytoplasmic vesicle, Endomembrane system, Lipid-anchor, autophagosome, autophagosome membrane, cytoskeleton.
MAP1LC3C, also named as LC3C, belongs to the MAP1 LC3 family. It is the human homolog of yeast Atg8 and is involved in the formation of autophagosomal vacuoles, called autophagosomes. LC3C is produced by the proteolytic cleavage after the conserved C-terminal Gly residue. The antibody is specific to the prepeptide of LC3C.
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Protein Aliases: Autoph; Autophagy-related protein LC3 C; Autophagy-related ubiquitin-like modifier LC3 C; LC3-like protein 2; MAP1 light chain 3-like protein 2; MAP1 light chain 3-like protein 3; MAP1A/MAP1B LC3 C; MAP1A/MAP1B light chain 3 C; Microtubule-associated protein 1 light chain 3 gamma; Microtubule-associated proteins 1A/1B light chain 3C
Gene Aliases: ATG8J; LC3C; MAP1LC3C
UniProt ID: (Human) Q9BXW4
Entrez Gene ID: (Human) 440738
Molecular Function: non-motor microtubule binding protein