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MAP3K7 Monoclonal Antibody (2E10)

View all (59) TAK1 antibodies

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MAP3K7 Monoclonal Antibody (2E10)

Product Details

H00006885-M02

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1 ng/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

2E10

Immunogen

MAP3K7 (AAH17715, 1 a.a. approximately 579 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MSTASAASSS SSSSAGEMIE APSQVLNFEE IDYKEIEVEE VVGRGAFGVV CKAKWRAKDV AIKQIESESE RKAFIVELRQ LSRVNHPNIV KLYGACLNPV CLVMEYAEGG SLYNVLHGAE PLPYYTAAHA MSWCLQCSQG VAYLHSMQPK ALIHRDLKPP NLLLVAGGTV LKICDFGTAC DIQTHMTNNK GSAAWMAPEV FEGSNYSEKC DVFSWGIILW EVITRRKPFD EIGGPAFRIM WAVHNGTRPP LIKNLPKPIE SLMTRCWSKD PSQRPSMEEI VKIMTHLMRY FPGADEPLQY PCQYSDEGQS NSATSTGSFM DIASTNTSNK SDTNMEQVPA TNDTIKRLES KLLKNQAKQQ SESGRLSLGA SRGSSVESLP PTSEGKRMSA DMSEIEARIA ATTGNGQPRR RSIQDLTVTG TEPGQVSSRS SSPSVRMITT SGPTSEKPTR SHPWTPDDST DTNGSDNSIP MAYLTLDHQL QPLAPCPNSK ESMAVFEQHC KMAQEYMKVQ TEIALLLQRK QELVAELDQD EKDQQNTSRL VQEHKKLLDE NKSLSTYYQQ CKKQLEVIRS QQQKRQGTS

Target Information

TAK1 (also known as MAP3K7), a part of the serine/threonine kinase family, is a versatile protein with many signaling functions. Originally identified as a TGF- beta-activated kinase, TAK1 interacts with TGF- beta-receptor and TRAF6 to modulate TGF- beta activation of JNK and p38. It has additional roles in activation of p38 and JNK through Wnt, BMP, and activin signaling pathways as well in response to thyroid hormone, osmotic stress, endothelin, and ephrine. Through activation of von Hippel-Lindau tumor suppressor expression, TAK1 represses PDGF-B, integrin beta1 and integrin beta5, promoting proper wound healing. TAK1 also plays an essential role in IKK activation in numerous signaling pathways including IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I. Activation of the TAK1-IKK pathway requires TAB2/3 and ubiquitination. In this process, TAB2/3 binds to the C-terminal region of TAK1 and becomes polyubiquitinated, TAK1 is autophosphorylated at Thr178, Thr184, Thr187 and Ser192, and finally TAK1 phosphorylates IKK- beta. Additionally, TAK1 represses human telomerase reverse transcriptase suggesting a role in regulation of cell lifespan.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: M3K7; RP1-154G14.1; TAK1d; TGF-beta activated kinase 1; transforming growth factor-beta-activated kinase 1; unnamed protein product

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Gene Aliases: CSCF; FMD2; MEKK7; TAK1; TGF1a

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UniProt ID: (Human) O43318

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Entrez Gene ID: (Human) 6885

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Function(s)
magnesium ion binding transcription coactivator binding protein kinase activity protein serine/threonine kinase activity MAP kinase activity MAP kinase kinase activity MAP kinase kinase kinase activity receptor binding type II transforming growth factor beta receptor binding protein binding ATP binding MAP kinase kinase kinase kinase activity kinase activity protein kinase binding receptor tyrosine kinase binding ubiquitin protein ligase binding histone kinase activity identical protein binding scaffold protein binding protein serine kinase activity protein serine/threonine kinase binding DNA-binding transcription factor binding linear polyubiquitin binding
Process(es)
MAPK cascade osteoblast differentiation response to hypoxia stimulatory C-type lectin receptor signaling pathway positive regulation of T cell cytokine production cytoplasmic pattern recognition receptor signaling pathway MyD88-dependent toll-like receptor signaling pathway chromatin remodeling inflammatory response immune response signal transduction transforming growth factor beta receptor signaling pathway I-kappaB kinase/NF-kappaB signaling I-kappaB phosphorylation JNK cascade positive regulation of autophagy negative regulation of gene expression positive regulation of macroautophagy positive regulation of interleukin-2 production toll-like receptor 3 signaling pathway toll-like receptor 4 signaling pathway TRIF-dependent toll-like receptor signaling pathway nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway p38MAPK cascade Fc-epsilon receptor signaling pathway interleukin-33-mediated signaling pathway interleukin-17A-mediated signaling pathway defense response to bacterium signal transduction in response to DNA damage positive regulation of I-kappaB kinase/NF-kappaB signaling anoikis regulation of MAPK cascade positive regulation of MAPK cascade positive regulation of JUN kinase activity positive regulation of cell cycle positive regulation of cell size T cell receptor signaling pathway stress-activated MAPK cascade bone development negative regulation of necroptotic process interleukin-1-mediated signaling pathway cellular response to tumor necrosis factor cellular response to hypoxia cellular response to transforming growth factor beta stimulus positive regulation of cGAS/STING signaling pathway positive regulation of NIK/NF-kappaB signaling cellular response to angiotensin positive regulation of vascular smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration response to angiotensin negative regulation of reactive oxygen species metabolic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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